Structure of PDB 1naa Chain B

Receptor sequence

>1naaB (length=541)

TPYDYIIVGAGPGGIIAADRLSEAGKKVLLLERGGPSTKQTGGTYVAPWA
TSSGLTKFDIPGLFESLFTDSNPFWWCKDITVFAGCLVGGGTSVNGALYW
YPNDGDFSSSVGWPSSWTNHAPYTSKLSSRLPSTDHPSTDGQRYLEQSFN
VVSQLLKGQGYNQATINDNPNYKDHVFGYSAFDFLNGKRAGPVATYLQTA
LARPNFTFKTNVMVSNVVRNGSQILGVQTNDPTLGPNGFIPVTPKGRVIL
SAGAFGTSRILFQSGIGPTDMIQTVQSNPTAAAALPPQNQWINLPVGMNA
QDNPSINLVFTHPSIDAYENWADVWSNPRPADAAQYLANQSGVFAGASPK
LNFWRAYSGSDGFTRYAQGTVRPGAASVNSSLPYNASQIFTITVYLSTGI
QSRGRIGIDAALRGTVLTPPWLVNPVDKTVLLQALHDVVSNIGSIPGLTM
ITPDVTQTLEEYVDAYDPATMNSNHWVSSTTIGSSPQSAVVDSNVKVFGT
NNLFIVDAGIIPHLPTGNPQGTLMSAAEQAAAKILALAGGP

3D structure

• PDB: 1naa Mechanism of the reductive half-reaction in cellobiose dehydrogenase
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y609 H689 N732
• Catalytic site (residue number reindexed from 1): Y395 H475 N518
• Enzyme Commision number: 1.1.99.18: cellobiose dehydrogenase (acceptor).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	6FA	B	V222 G223 P226 E246 R247 F278 F282 G299 C300 G304 G305 N309 G310 A311 L312 M427 V428 A466 G467 N688 D721 A722 N732 P733 Q734 L737	V8 G9 P12 E32 R33 F64 F68 G85 C86 G90 G91 N95 G96 A97 L98 M213 V214 A252 G253 N474 D507 A508 N518 P519 Q520 L523
BS02	ABL	B	F278 E279 P563 R586 S687 N688 H689 N732	F64 E65 P349 R372 S473 N474 H475 N518	MOAD: Ki=0.25mM

Gene Ontology

Molecular Function

• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:1naa, PDBe:1naa, PDBj:1naa
• PDBsum: 1naa
• PubMed: 12493734
• UniProt: Q01738|CDH_PHACH Cellobiose dehydrogenase (Gene Name=CDH-1)