Structure of PDB 1n63 Chain B

Receptor sequence

>1n63B (length=805) Species: 504832 (Afipia carboxidovorans OM5)

TTVEPTSAERAEKLQGMGCKRKRVEDIRFTQGKGNYVDDVKLPGMLFGDF
VRSSHAHARIKSIDTSKAKALPGVFAVLTAADLKPLNLHYMPTLAGDVQA
VLADEKVLFQNQEVAFVVAKDRYVAADAIELVEVDYEPLPVLVDPFKAME
PDAPLLREDIKDKMTGAHGARKHHNHIFRWEIGDKEGTDATFAKAEVVSK
DMFTYHRVHPSPLETCQCVASMDKIKGELTLWGTFQAPHVIRTVVSLISG
LPEHKIHVIAPDIGGGFGNKVGAYSGYVCAVVASIVLGVPVKWVEDRMEN
LSTTSFARDYHMTTELAATKDGKILAMRCHVLADHGAFDACADPSKWPAG
FMNICTGSYDMPVAHLAVDGVYTNKASGGVAYRCSFRVTEAVYAIERAIE
TLAQRLEMDSADLRIKNFIQPEQFPYMAPLGWEYDSGNYPLAMKKAMDTV
GYHQLRAEQKAKQEAFKRGETREIMGIGISFFTEIVGAGPSKNCDILGVS
MFDSAEIRIHPTGSVIARMGTKSQGQGHETTYAQIIATELGIPADDIMIE
EGNTDTAPYGLGTYGSRSTPTAGAATAVAARKIKAKAQMIAAHMLEVHEG
DLEWDVDRFRVKGLPEKFKTMKELAWASYNSPPPNLEPGLEAVNYYDPPN
MTYPFGAYFCIMDIDVDTGVAKTRRFYALDDCGTRINPMIIEGQVHGGLT
EAFAVAMGQEIRYDEQGNVLGASFMDFFLPTAVETPKWETDYTVTPSPHH
PIGAKGVGESPHVGGVPCFSNAVNDAYAFLNAGHIQMPHDAWRLWKVGEQ
LGLHV

3D structure

• PDB: 1n63 Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
• Chain: B
• Resolution: 1.21 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q240 V275 P352 I358 R387 C388 E763 S764
• Catalytic site (residue number reindexed from 1): Q236 V271 P348 I354 R383 C384 E759 S760
• Enzyme Commision number: 1.2.5.3: aerobic carbon monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CUN	B	G272 A385 R387 C388 Y568 G569 E763	G268 A381 R383 C384 Y564 G565 E759
BS02	MCN	B	G270 F271 R387 Q528 G529 Q530 H532 T535 T567 Y568 S570 S572 T573 C686 I690 I694 I695 Q698 K759 G760 V761 E763	G266 F267 R383 Q524 G525 Q526 H528 T531 T563 Y564 S566 S568 T569 C682 I686 I690 I691 Q694 K755 G756 V757 E759

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005507 copper ion binding
• GO:0008805 carbon-monoxide oxygenase activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:1n63, PDBe:1n63, PDBj:1n63
• PDBsum: 1n63
• PubMed: 12475995
• UniProt: P19919|DCML_AFIC5 Carbon monoxide dehydrogenase large chain (Gene Name=coxL)