Structure of PDB 1n60 Chain B

Receptor sequence

>1n60B (length=803) Species: 504832 (Afipia carboxidovorans OM5)

VEPTSAERAEKLQGMGCKRKRVEDIRFTQGKGNYVDDVKLPGMLFGDFVR
SSHAHARIKSIDTSKAKALPGVFAVLTAADLKPLNLHYMPTLAGDVQAVL
ADEKVLFQNQEVAFVVAKDRYVAADAIELVEVDYEPLPVLVDPFKAMEPD
APLLREDIKDKMTGAHGARKHHNHIFRWEIGDKEGTDATFAKAEVVSKDM
FTYHRVHPSPLETCQCVASMDKIKGELTLWGTFQAPHVIRTVVSLISGLP
EHKIHVIAPDIGGGFGNKVGAYSGYVCAVVASIVLGVPVKWVEDRMENLS
TTSFARDYHMTTELAATKDGKILAMRCHVLADHGAFDACADPSKWPAGFM
NICTGSYDMPVAHLAVDGVYTNKASGGVAYRCSFRVTEAVYAIERAIETL
AQRLEMDSADLRIKNFIQPEQFPYMAPLGWEYDSGNYPLAMKKAMDTVGY
HQLRAEQKAKQEAFKRGETREIMGIGISFFTEIVGAGPSKNCDILGVSMF
DSAEIRIHPTGSVIARMGTKSQGQGHETTYAQIIATELGIPADDIMIEEG
NTDTAPYGLGTYGSRSTPTAGAATAVAARKIKAKAQMIAAHMLEVHEGDL
EWDVDRFRVKGLPEKFKTMKELAWASYNSPPPNLEPGLEAVNYYDPPNMT
YPFGAYFCIMDIDVDTGVAKTRRFYALDDCGTRINPMIIEGQVHGGLTEA
FAVAMGQEIRYDEQGNVLGASFMDFFLPTAVETPKWETDYTVTPSPHHPI
GAKGVGESPHVGGVPCFSNAVNDAYAFLNAGHIQMPHDAWRLWKVGEQLG
LHV

3D structure

• PDB: 1n60 Catalysis at a dinuclear [CuSMo(=O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution
• Chain: B
• Resolution: 1.19 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q240 V275 P352 I358 R387 C388 E763 S764
• Catalytic site (residue number reindexed from 1): Q234 V269 P346 I352 R381 C382 E757 S758
• Enzyme Commision number: 1.2.5.3: aerobic carbon monoxide dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	OMO	B	F271 G272 Y568 G569 E763	F265 G266 Y562 G563 E757
BS02	MCN	B	G270 F271 R387 Q528 G529 Q530 H532 T535 T567 Y568 G569 S570 S572 T573 C686 I690 I694 I695 Q698 K759 G760 V761 E763	G264 F265 R381 Q522 G523 Q524 H526 T529 T561 Y562 G563 S564 S566 T567 C680 I684 I688 I689 Q692 K753 G754 V755 E757

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005507 copper ion binding
• GO:0008805 carbon-monoxide oxygenase activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043885 anaerobic carbon-monoxide dehydrogenase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:1n60, PDBe:1n60, PDBj:1n60
• PDBsum: 1n60
• PubMed: 12475995
• UniProt: P19919|DCML_AFIC5 Carbon monoxide dehydrogenase large chain (Gene Name=coxL)