Structure of PDB 1mzj Chain B

Receptor sequence
>1mzjB (length=334) Species: 140437 (Streptomyces sp. R1128) [Search protein sequence]
PGLRVPERRFSRVLGVGSYRPRREVSNKEVCTWIDSTEEWIETRTGIRSR
RIAEPDETIQVMGVAASRRALEHAGVDPAEIDLVVVSTMTNFVHTPPLSV
AIAHELGADNAGGFDLSAACAGFCHALSIAADAVESGGSRHVLVVATERM
TDVIDLADRSLSFLFGDGAGAAVVGPSDVPGIGPVVRGIDGTGLGSLHMS
SSWDQYVEDPSVGRPALVMDGKRVFRWAVADVVPAAREALEVAGLTVGDL
VAFVPHQANLRIIDVLVDRLGVPEHVVVSRDAEDTGNTSSASVALALDRL
VRSGAVPGGGPALMIGFGAGLSYAGQALLLPDPP
3D structure
PDB1mzj Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.180: beta-ketoacyl-[acyl-carrier-protein] synthase III.
2.3.1.300: branched-chain beta-ketoacyl-[acyl-carrier-protein] synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA B S37 W41 R45 R160 F166 M220 G222 A259 N260 N288 S36 W40 R44 R159 F165 M219 G221 A258 N259 N287
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0044550 secondary metabolite biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mzj, PDBe:1mzj, PDBj:1mzj
PDBsum1mzj
PubMed12429097
UniProtQ9F6D4|FABH_STRLI Beta-ketoacyl-[acyl-carrier-protein] synthase III (Gene Name=fabH)

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