Structure of PDB 1mui Chain B

Receptor sequence
>1muiB (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
3D structure
PDB1mui X-ray Crystallographic Structure of ABT-378 (Lopinavir) Bound to HIV-1 Protease
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AB1 B D25 G27 A28 D29 G48 G49 P81 V82 I84 D25 G27 A28 D29 G48 G49 P81 V82 I84 PDBbind-CN: -logKd/Ki=11.89,Ki=1.3pM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1mui, PDBe:1mui, PDBj:1mui
PDBsum1mui
PubMed12057670
UniProtQ903J0

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