Structure of PDB 1mqb Chain B

Receptor sequence
>1mqbB (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
LKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTKEVPVAIKTLKAGYTEK
QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLR
EKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKV
SDFGLSRVLKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPY
WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIV
SILDKLIRAPDSLKT
3D structure
PDB1mqb Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 P780
Catalytic site (residue number reindexed from 1) D134 A136 R138 N139 D152 P162
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B I619 G622 V627 A644 K646 M695 N744 L746 D757 I18 G21 V26 A39 K41 M90 N139 L141 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1mqb, PDBe:1mqb, PDBj:1mqb
PDBsum1mqb
PubMed12467573
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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