Structure of PDB 1mhw Chain B

Receptor sequence
>1mhwB (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSE
QNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKY
NPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI
YFEPDCSSEDMDHGVLVVGYGFES
3D structure
PDB1mhw Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.15: cathepsin L.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N18 L144 N18 L144
BS02 peptide B Q21 E141 F145 Q21 E141 F145
BS03 peptide B Q19 Q21 C22 A25 G61 E63 G67 G68 L69 M70 A135 D162 H163 Q19 Q21 C22 A25 G61 E63 G67 G68 L69 M70 A135 D162 H163
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1mhw, PDBe:1mhw, PDBj:1mhw
PDBsum1mhw
PubMed12431059
UniProtP07711|CATL1_HUMAN Procathepsin L (Gene Name=CTSL)

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