Structure of PDB 1mhd Chain B

Receptor sequence
>1mhdB (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
PIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQN
VNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELC
EFAFNMKKDEVCVNPYHYQRVET
3D structure
PDB1mhd Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R74 K81 R65 K72 PDBbind-CN: Kd=114nM
BS02 dna B S70 L71 Q76 K81 S61 L62 Q67 K72 PDBbind-CN: Kd=114nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005667 transcription regulator complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1mhd, PDBe:1mhd, PDBj:1mhd
PDBsum1mhd
PubMed9741623
UniProtP84022|SMAD3_HUMAN Mothers against decapentaplegic homolog 3 (Gene Name=SMAD3)

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