Structure of PDB 1m8y Chain B

Receptor sequence
>1m8yB (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYM
3D structure
PDB1m8y MODULAR RECOGNITION OF RNA BY A HUMAN PUMILIO-HOMOLOGY DOMAIN
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q860 R864 Q867 F897 N899 Y900 Y933 R936 Q939 H972 R1008 Q1011 N1043 Y1044 Q1047 K1076 F1077 N1080 E1083 Y1120 N1122 Y1123 H1159 Q33 R37 Q40 F70 N72 Y73 Y106 R109 Q112 H145 R181 Q184 N216 Y217 Q220 K249 F250 N253 E256 Y293 N295 Y296 H332 PDBbind-CN: Kd=160nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:1m8y, PDBe:1m8y, PDBj:1m8y
PDBsum1m8y
PubMed12202039
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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