Structure of PDB 1lpa Chain B

Receptor sequence
>1lpaB (length=449) Species: 9606 (Homo sapiens) [Search protein sequence]
KEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNF
QEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESV
NCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVI
GHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFV
DVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDID
GIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPC
PSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGK
KVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVK
FIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
3D structure
PDB1lpa Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography.
ChainB
Resolution3.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F77 S152 L153 D176 H263
Catalytic site (residue number reindexed from 1) F78 S153 L154 D177 H264
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E187 L188 R190 L191 D192 D195 E188 L189 R191 L192 D193 D196
Gene Ontology
Molecular Function
GO:0004806 triacylglycerol lipase activity
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0030299 intestinal cholesterol absorption
GO:0042572 retinol metabolic process
GO:0061365 positive regulation of triglyceride lipase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1lpa, PDBe:1lpa, PDBj:1lpa
PDBsum1lpa
PubMed8479519
UniProtP16233|LIPP_HUMAN Pancreatic triacylglycerol lipase (Gene Name=PNLIP)

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