Structure of PDB 1lh0 Chain B

Receptor sequence
>1lh0B (length=206) [Search protein sequence]
MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLG
RFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRK
EGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLDRQ
ERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVRAY
REEFGV
3D structure
PDB1lh0 Structure of Salmonella typhimurium OMP Synthase in a Complete Substrate Complex.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRP B K2026 Y2072 K2073 K2100 D2124 D2125 V2126 T2128 A2129 G2130 T2131 A2132 K26 Y72 K73 K100 D117 D118 V119 T121 A122 G123 T124 A125
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004588 orotate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1lh0, PDBe:1lh0, PDBj:1lh0
PDBsum1lh0
PubMed22531064
UniProtP08870|PYRE_SALTY Orotate phosphoribosyltransferase (Gene Name=pyrE)

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