Structure of PDB 1lco Chain B

Receptor sequence
>1lcoB (length=391) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAFYSSGANDE
VTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATALCK
LGNPLEGEKDVARGCGQGVTKVPQMISTLASCSPEEIIEAAPSDKQIQWY
QLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKQGASR
ALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVVL
SNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVLK
ALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTSI
AELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
3D structure
PDB1lco X-ray structure of two complexes of the Y143F flavocytochrome b2 mutant crystallized in the presence of lactate or phenyl lactate.
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S228 Y254 T280 D282 K349 H373
Catalytic site (residue number reindexed from 1) S127 Y153 T179 D181 K229 H253
Enzyme Commision number 1.1.2.3: L-lactate dehydrogenase (cytochrome).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B Y144 S195 A196 T197 A198 S228 Q252 Y254 T280 K349 H373 D409 R413 G432 R433 Y43 S94 A95 T96 A97 S127 Q151 Y153 T179 K229 H253 D289 R293 G312 R313
BS02 PPY B F143 A198 L199 H373 R376 F42 A97 L98 H253 R256
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:1lco, PDBe:1lco, PDBj:1lco
PDBsum1lco
PubMed7632684
UniProtP00175|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)

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