Structure of PDB 1kqc Chain B

Receptor sequence
>1kqcB (length=216) Species: 550 (Enterobacter cloacae) [Search protein sequence]
DIISVALKRHSTKAFDASKKLTAEEAEKIKTLLQYSPSSTNSQPWHFIVA
STEEGKARVAKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQ
EEADGRFNTPEAKAANHKGRTYFADMHRVDLKDDDQWMAKQVYLNVGNFL
LGVGAMGLDAVPIEGFDAAILDEEFGLKEKGFTSLVVVPVGHHSVEDFNA
TLPKSRLPLSTIVTEC
3D structure
PDB1kqc Structures of nitroreductase in three states: effects of inhibitor binding and reduction.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K14 K74 E165
Catalytic site (residue number reindexed from 1) K13 K73 E164
Enzyme Commision number 1.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN B P38 S39 S40 N42 P37 S38 S39 N41
BS02 ACT B T41 F124 T40 F123
BS03 FMN B R10 H11 S12 K14 N71 K74 P163 I164 E165 G166 K205 R207 R9 H10 S11 K13 N70 K73 P162 I163 E164 G165 K204 R206
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0046256 2,4,6-trinitrotoluene catabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1kqc, PDBe:1kqc, PDBj:1kqc
PDBsum1kqc
PubMed11805110
UniProtQ01234|NFSB_ENTCL Oxygen-insensitive NAD(P)H nitroreductase (Gene Name=nfsB)

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