Structure of PDB 1keu Chain B

Receptor sequence
>1keuB (length=361) Species: 90371 (Salmonella enterica subsp. enterica serovar Typhimurium) [Search protein sequence]
MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESN
RYNFEHADICDSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETN
IVGTYALLEVARKYWSALGEDKKNNFRFHHISTDEVYGDLPHPDEVENSV
TLPLFTETTAYAPSSPYSASKASSDHLVRAWRRTYGLPTIVTNCSNNYGP
YHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHARALHMVVTEG
KAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGH
DRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQWVNNVKSGAYQ
SWIEQNYEGRQ
3D structure
PDB1keu Toward a structural understanding of the dehydratase mechanism.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T133 D134 E135 L152 L154 F155 T158 Y167 K171
Catalytic site (residue number reindexed from 1) T133 D134 E135 L152 L154 F155 T158 Y167 K171
Enzyme Commision number 4.2.1.46: dTDP-glucose 4,6-dehydratase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0008460 dTDP-glucose 4,6-dehydratase activity
GO:0016829 lyase activity
GO:0070404 NADH binding
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009225 nucleotide-sugar metabolic process
GO:0009243 O antigen biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1keu, PDBe:1keu, PDBj:1keu
PDBsum1keu
PubMed11796113
UniProtP26391|RMLB_SALTY dTDP-glucose 4,6-dehydratase (Gene Name=rfbB)

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