Structure of PDB 1k6t Chain B

Receptor sequence

>1k6tB (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGI
GGFIKVRQYDQIPIEICGHKAIGTVLVGPTPTNVIGRNLLTQIGCTLNF

3D structure

• PDB: 1k6t Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease.
• Chain: B
• Resolution: 2.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27
• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XN1	B	D25 G27 A28 D29 D30 V32 I47 G48 P81	D25 G27 A28 D29 D30 V32 I47 G48 P81	MOAD: Kd=24nM PDBbind-CN: -logKd/Ki=7.62,Kd=24nM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1k6t, PDBe:1k6t, PDBj:1k6t
• PDBsum: 1k6t
• PubMed: 11790852
• UniProt: P35963|POL_HV1Y2 Gag-Pol polyprotein (Gene Name=gag-pol)