Structure of PDB 1js6 Chain B

Receptor sequence

>1js6B (length=464) Species: 9823 (Sus scrofa)

MNASDFRRRGKEMVDYMADYLEGIEGRQVYPDVQPGYLRPLIPATAPQEP
DTFEDILQDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGC
IGFSWAASPACTELETVMMDWLGKMLQLPEAFLAGEAGEGGGVIQGSASE
ATLVALLAARTKVVRRLQAASPGLTQGAVLEKLVAYASDQAHSSVERAGL
IGGVKLKAIPSDGKFAMRASALQEALERDKAAGLIPFFVVATLGTTSCCS
FDNLLEVGPICHEEDIWLHVDAAYAGSAFICPEFRHLLNGVEFADSFNFN
PHKWLLVNFDCSAMWVKRRTDLTGAFKSGLITDYRHWQLPLGRRFRSLKM
WFVFRMYGVKGLQAYIRKHVQLSHEFEAFVLQDPRFEVCAEVTLGLVCFR
LKGSDGLNEALLERINSARKIHLVPCRLRGQFVLRFAICSRKVESGHVRL
AWEHIRGLAAELLA

3D structure

• PDB: 1js6 Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.28: aromatic-L-amino-acid decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	B	F80 S147 A148 S149 H192 T246 D271 A273 N300 H302 K303	F80 S147 A148 S149 H192 T246 D271 A273 N300 H302 K303

Gene Ontology

Molecular Function

• GO:0004058 aromatic-L-amino-acid decarboxylase activity
• GO:0016830 carbon-carbon lyase activity
• GO:0016831 carboxy-lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity
• GO:0036468 L-dopa decarboxylase activity

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0006584 catecholamine metabolic process
• GO:0019752 carboxylic acid metabolic process
• GO:0042416 dopamine biosynthetic process
• GO:0042423 catecholamine biosynthetic process
• GO:0042427 serotonin biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1js6, PDBe:1js6, PDBj:1js6
• PDBsum: 1js6
• PubMed: 11685243
• UniProt: P80041|DDC_PIG Aromatic-L-amino-acid decarboxylase (Gene Name=DDC)