Structure of PDB 1jqe Chain B

Receptor sequence
>1jqeB (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
GKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGG
AGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKISNLENVK
FAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLL
GTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLG
LKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAEL
GKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
3D structure
PDB1jqe Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.
ChainB
Resolution1.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.8: histamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G60 G62 I66 E89 P90 Q94 T119 S120 I142 Q143 M144 Y147 G48 G50 I54 E77 P78 Q82 T107 S108 I130 Q131 M132 Y135 BindingDB: Ki=18100nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0001692 histamine metabolic process
GO:0001695 histamine catabolic process
GO:0006548 L-histidine catabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0032259 methylation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jqe, PDBe:1jqe, PDBj:1jqe
PDBsum1jqe
PubMed11566133
UniProtP50135|HNMT_HUMAN Histamine N-methyltransferase (Gene Name=HNMT)

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