Structure of PDB 1jqd Chain B

Receptor sequence
>1jqdB (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
MRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEI
KILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAK
TSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPAT
LKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDL
TQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATA
PPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
3D structure
PDB1jqd Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.
ChainB
Resolution2.28 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.8: histamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B G60 G62 E89 P90 Q94 T119 S120 I142 Q143 M144 Y147 G56 G58 E85 P86 Q90 T115 S116 I138 Q139 M140 Y143 MOAD: Ki=6.9uM
BindingDB: Ki=18100nM
BS02 HSM B F22 E28 Q143 Y146 W179 N283 F18 E24 Q139 Y142 W175 N279
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0046539 histamine N-methyltransferase activity
Biological Process
GO:0001692 histamine metabolic process
GO:0001695 histamine catabolic process
GO:0006548 L-histidine catabolic process
GO:0007585 respiratory gaseous exchange by respiratory system
GO:0032259 methylation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1jqd, PDBe:1jqd, PDBj:1jqd
PDBsum1jqd
PubMed11566133
UniProtP50135|HNMT_HUMAN Histamine N-methyltransferase (Gene Name=HNMT)

[Back to BioLiP]