Structure of PDB 1jg3 Chain B

Receptor sequence
>1jg3B (length=215) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
EKELYEKWMRTVEMLKAEGIIRSKEVERAFLKYPRYLSVEDKYKKYAHID
EPLPIPAGQTVSAPHMVAIMLEIANLKPGMNILEVGTGSGWNAALISEIV
KTDVYTIERIPELVEFAKRNLERAGVKNVHVILGDGSKGFPPKAPYDVII
VTAGAPKIPEPLIEQLKIGGKLIIPVGSYHLWQELLEVRKTKDGIKIKNH
GGVAFVPLIGEYGWK
3D structure
PDB1jg3 Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S75
Catalytic site (residue number reindexed from 1) S62
Enzyme Commision number 2.1.1.77: protein-L-isoaspartate(D-aspartate) O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B P65 P67 T73 S75 A76 H78 M79 V216 A217 F218 V219 P52 P54 T60 S62 A63 H65 M66 V203 A204 F205 V206
BS02 ADN B Q72 G99 E121 R122 G147 D148 G149 T165 L221 I222 Q59 G86 E108 R109 G134 D135 G136 T152 L208 I209
Gene Ontology
Molecular Function
GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0030091 protein repair
GO:0032259 methylation
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1jg3, PDBe:1jg3, PDBj:1jg3
PDBsum1jg3
PubMed11700066
UniProtQ8TZR3|PIMT_PYRFU Protein-L-isoaspartate O-methyltransferase (Gene Name=pcm)

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