Structure of PDB 1jfi Chain B

Receptor sequence

>1jfiB (length=135) Species: 9606 (Homo sapiens) [Search protein sequence]

DDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEIC
NKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRL
ENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQ

3D structure

PDB

1jfi Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.

Chain

Resolution

2.62 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K164 R202	K56 R94
BS02	dna	B	R115 R201	R7 R93

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0016251	RNA polymerase II general transcription initiation factor activity
GO:0017025	TBP-class protein binding
GO:0046982	protein heterodimerization activity
GO:0140223	general transcription initiation factor activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II
GO:0045995	regulation of embryonic development
GO:0051123	RNA polymerase II preinitiation complex assembly
GO:0051302	regulation of cell division
GO:0051726	regulation of cell cycle
GO:0090043	regulation of tubulin deacetylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0017054	negative cofactor 2 complex
GO:0072686	mitotic spindle
GO:0090575	RNA polymerase II transcription regulator complex
GO:0140672	ATAC complex

External links

PDB	RCSB:1jfi, PDBe:1jfi, PDBj:1jfi
PDBsum	1jfi
PubMed	11461703
UniProt	Q01658\|NC2B_HUMAN Protein Dr1 (Gene Name=DR1)