Structure of PDB 1jey Chain B

Receptor sequence
>1jeyB (length=530) Species: 9606 (Homo sapiens) [Search protein sequence]
NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIA
LVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQA
DFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLK
KCDISLQFFLPFSLGGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISL
EGEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYK
SILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFR
YGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVF
AARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHN
YECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAK
KDEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNM
LNPPAEVTTKSQIPLSKIKTLFPLIEAKKK
3D structure
PDB1jey Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B T275 K338 D398 K399 R400 T260 K323 D383 K384 R385 PDBbind-CN: Kd=0.15nM
BS02 dna B E53 L85 K126 R242 K265 Y397 R400 A401 N402 E48 L80 K121 R227 K250 Y382 R385 A386 N387 PDBbind-CN: Kd=0.15nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jey, PDBe:1jey, PDBj:1jey
PDBsum1jey
PubMed11493912
UniProtP13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)

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