Structure of PDB 1jeh Chain B

Receptor sequence
>1jehB (length=478) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI
PSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTG
GIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNII
VATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGS
VYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISA
KRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE
VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTG
HGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAK
TNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDV
ARVCHAHPTLSEAFKEANMAAYDKAIHC
3D structure
PDB1jeh Crystal structure of eucaryotic E3, lipoamide dehydrogenase from yeast.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L40 C44 C49 S52 I193 E197 T349 H455 H457 E462
Catalytic site (residue number reindexed from 1) L40 C44 C49 S52 I193 E197 T349 H455 H457 E462
Enzyme Commision number 1.8.1.4: dihydrolipoyl dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I11 G14 P15 A16 E35 K36 R37 G42 T43 C44 G48 C49 K53 N117 G118 T153 G154 S173 I194 Y288 L292 G324 D325 M331 L332 A333 I11 G14 P15 A16 E35 K36 R37 G42 T43 C44 G48 C49 K53 N117 G118 T153 G154 S173 I194 Y288 L292 G324 D325 M331 L332 A333
Gene Ontology
Molecular Function
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0004738 pyruvate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006086 acetyl-CoA biosynthetic process from pyruvate
GO:0006090 pyruvate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006103 2-oxoglutarate metabolic process
GO:0006546 glycine catabolic process
GO:0006550 isoleucine catabolic process
GO:0006552 L-leucine catabolic process
GO:0006564 L-serine biosynthetic process
GO:0006574 valine catabolic process
GO:0042743 hydrogen peroxide metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005960 glycine cleavage complex
GO:0042645 mitochondrial nucleoid
GO:0045252 oxoglutarate dehydrogenase complex
GO:0045254 pyruvate dehydrogenase complex

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Cellular Component
External links
PDB RCSB:1jeh, PDBe:1jeh, PDBj:1jeh
PDBsum1jeh
PubMed9538259
UniProtP09624|DLDH_YEAST Dihydrolipoyl dehydrogenase, mitochondrial (Gene Name=LPD1)

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