Structure of PDB 1jcx Chain B

Receptor sequence
>1jcxB (length=254) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
KFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSI
HSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPA
FLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLT
ERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGMREFIFPLIRA
AVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVASKY
YETI
3D structure
PDB1jcx Structures of Aquifex aeolicus KDO8P synthase in complex with R5P and PEP, and with a bisubstrate inhibitor: role of active site water in catalysis.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.55: 3-deoxy-8-phosphooctulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAI B K2041 K2046 N2048 R2049 S2050 Q2099 P2101 A2102 K2124 R2154 H2185 F2220 K39 K44 N46 R47 S48 Q97 P99 A100 K122 R152 H183 F210 MOAD: Ki=7uM
PDBbind-CN: -logKd/Ki=5.15,Ki=7.0uM
Gene Ontology
Molecular Function
GO:0008676 3-deoxy-8-phosphooctulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
GO:0046364 monosaccharide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jcx, PDBe:1jcx, PDBj:1jcx
PDBsum1jcx
PubMed11747443
UniProtO66496|KDSA_AQUAE 2-dehydro-3-deoxyphosphooctonate aldolase (Gene Name=kdsA)

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