Structure of PDB 1ivf Chain B

Receptor sequence

>1ivfB (length=388) Species: 380960 (Influenza A virus (A/Tokyo/3/1967(H2N2)))

VEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPVKCYQ
FALGQGTTLDNKHSNDTVHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSS
SCHDGKAWLHVCITGDDKNATASFIYDGRLVDSIGSWSQNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLAGSAQHVEECSCY
PRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDR
SSNSNCRDPNNERGTQGVKGWAFDNGNDLWMGRTISKDLRSGYETFKVIG
GWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINRCFYVELIRGRK
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

3D structure

• PDB: 1ivf Structures of aromatic inhibitors of influenza virus neuraminidase.
• Chain: B
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D151 E277 R292 R371 Y406
• Catalytic site (residue number reindexed from 1): D70 E196 R211 R290 Y325
• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BMA	B	Q391 I392 R394	Q310 I311 R313
BS02	CA	B	D293 G297 D324 G345 T346 Q347	D212 G216 D243 G264 T265 Q266
BS03	DAN	B	E119 D151 R152 R224 A246 E276 R371 Y406	E38 D70 R71 R143 A165 E195 R290 Y325

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:1ivf, PDBe:1ivf, PDBj:1ivf
• PDBsum: 1ivf
• PubMed: 7880809
• UniProt: P06820|NRAM_I67A0 Neuraminidase (Gene Name=NA)