Structure of PDB 1is0 Chain B

Receptor sequence
>1is0B (length=102) Species: 11886 (Rous sarcoma virus) [Search protein sequence]
EEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK
GLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVC
PT
3D structure
PDB1is0 Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding.
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R155 R175 S177 E178 T179 C185 K200 H201 Y202 K203 R205 T215 R10 R30 S32 E33 T34 C40 K55 H56 Y57 K58 R60 T70
External links
PDB RCSB:1is0, PDBe:1is0, PDBj:1is0
PDBsum1is0
PubMed11782172
UniProtP00524|SRC_RSVSA Tyrosine-protein kinase transforming protein Src (Gene Name=V-SRC)

[Back to BioLiP]