Structure of PDB 1io8 Chain B

Receptor sequence
>1io8B (length=359) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
MYDWFSEMRKKDPVYYDGNIWQVLSYRYTKEVLNNFSKFSSDLTGYHERL
EDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIR
ETTRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDL
VAFRFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLL
IAGNETTTNLISNSVIDFTRFNLWQRIREENLYLKAIEEALRYSPPVMRT
VRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNPH
LSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVPNEVLNGY
KRLVVRLKS
3D structure
PDB1io8 Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F653 A709 E712 T713 T714 C817 L818 G819 E826 L854
Catalytic site (residue number reindexed from 1) F153 A202 E205 T206 T207 C310 L311 G312 E319 L347
Enzyme Commision number 1.11.1.7: peroxidase.
1.14.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B M568 H576 R580 L705 A709 G710 T713 T714 L717 T757 R759 S809 F810 H815 C817 L818 G819 A823 M68 H76 R80 L198 A202 G203 T206 T207 L210 T250 R252 S302 F303 H308 C310 L311 G312 A316
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004601 peroxidase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0140825 lactoperoxidase activity
Biological Process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1io8, PDBe:1io8, PDBj:1io8
PDBsum1io8
PubMed12237217
UniProtQ55080|CP119_SULAC Cytochrome P450 119 (Gene Name=cyp119)

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