Structure of PDB 1iic Chain B

Receptor sequence
>1iicB (length=422) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
AMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCS
IDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDW
HIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLT
PVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVD
FTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRF
ELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLP
FTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYD
ACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPIT
GGLNPDNSNDIKRRSNVGVVML
3D structure
PDB1iic Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 L455
Catalytic site (residue number reindexed from 1) N136 F137 L138 T172 L422
Enzyme Commision number 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYA B H38 K39 F40 W41 Y103 E105 I168 L171 V173 R178 S179 R181 T183 P184 I187 T191 W200 H201 Y204 T205 I208 L210 F425 H5 K6 F7 W8 Y70 E72 I135 L138 V140 R145 S146 R148 T150 P151 I154 T158 W167 H168 Y171 T172 I175 L177 F392
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006499 N-terminal protein myristoylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1iic, PDBe:1iic, PDBj:1iic
PDBsum1iic
PubMed11371195
UniProtP14743|NMT_YEAST Glycylpeptide N-tetradecanoyltransferase (Gene Name=NMT1)

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