Structure of PDB 1ie4 Chain B

Receptor sequence
>1ie4B (length=120) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SKCPLMVKVLDAVRGSPAVDVAVKVFKKTADGSWEPFASGKTAESGELHG
LTTDEKFTEGVYRVELDTKSYWKALGISPFHEYAEVVFTANDSGHRHYTI
AALLSPYSYSTTAVVSNPQN
3D structure
PDB1ie4 Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 T44 B K15 E54 A108 A109 L110 K8 E47 A101 A102 L103
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0042562 hormone binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0070324 thyroid hormone binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0007165 signal transduction
GO:0042403 thyroid hormone metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0032991 protein-containing complex

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External links
PDB RCSB:1ie4, PDBe:1ie4, PDBj:1ie4
PDBsum1ie4
PubMed11468389
UniProtP02767|TTHY_RAT Transthyretin (Gene Name=Ttr)

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