Structure of PDB 1ibc Chain B

Receptor sequence
>1ibcB (length=88) Species: 9606 (Homo sapiens) [Search protein sequence]
AIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV
EEIFRKVRFSFEQPAGRAQMPTTERVTLTRCFYLFPGH
3D structure
PDB1ibc A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).
ChainB
Resolution2.73 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E390
Catalytic site (residue number reindexed from 1) E74
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S339 W340 R341 H342 V348 R383 S23 W24 R25 H26 V32 R67
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ibc, PDBe:1ibc, PDBj:1ibc
PDBsum1ibc
PubMed9190289
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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