Structure of PDB 1i79 Chain B

Receptor sequence

>1i79B (length=61) Species: 9606 (Homo sapiens)

AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTK
TDKQEAYVLSE

3D structure

• PDB: 1i79 The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
• Chain: B
• Resolution: 2.01 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E67
• Catalytic site (residue number reindexed from 1): E61
• Enzyme Commision number: 4.1.1.50: adenosylmethionine decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MHZ	B	F7 L65 S66 E67	F4 L59 S60 E61

Gene Ontology

Molecular Function

• GO:0004014 adenosylmethionine decarboxylase activity

Biological Process

• GO:0008295 spermidine biosynthetic process

External links

• PDB: RCSB:1i79, PDBe:1i79, PDBj:1i79
• PDBsum: 1i79
• PubMed: 11583147
• UniProt: P17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)