Structure of PDB 1i74 Chain B

Receptor sequence
>1i74B (length=309) Species: 1309 (Streptococcus mutans) [Search protein sequence]
SKILVFGHQNPDSDAIGSSMAYAYLKRQLGVDAQAVALGNPNEETAFVLD
YFGIQAPPVVKSAQAEGAKQVILTDHNEFQQSIADIREVEVVEVVDHHRV
ANFETANPLYMRLEPVGSASSIVYRLYKENGVAIPKEIAGVMLSGLISDT
LLLKSPTTHASDPAVAEDLAKIAGVDLQEYGLAMLKAGTNLASKTAAQLV
DIDAKTFELNGSQVRVAQVNTVDINEVLERQNEIEEAIKASQAANGYSDF
VLMITDILNSNSEILALGNNTDKVEAAFNFTLKNNHAFLAGAVSRKKQVV
PQLTESFNG
3D structure
PDB1i74 Crystal structure of Streptococcus mutans pyrophosphatase: a new fold for an old mechanism.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B H8 D12 D75 H8 D12 D75
BS02 MN B D14 D75 H97 D149 D14 D75 H97 D149
BS03 SO4 B H97 H98 D149 H97 H98 D149
Gene Ontology
Molecular Function
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:1i74, PDBe:1i74, PDBj:1i74
PDBsum1i74
PubMed11525166
UniProtO68579|PPAC_STRMU Probable manganese-dependent inorganic pyrophosphatase (Gene Name=ppaC)

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