Structure of PDB 1i72 Chain B

Receptor sequence
>1i72B (length=61) Species: 9606 (Homo sapiens) [Search protein sequence]
AHFFEGTEKLLEVWFSRQQPQGSGDLRTIPRSEWDILLKDVQCSIISVTK
TDKQEAYVLSE
3D structure
PDB1i72 The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E67
Catalytic site (residue number reindexed from 1) E61
Enzyme Commision number 4.1.1.50: adenosylmethionine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAO B F7 L65 S66 E67 F4 L59 S60 E61 PDBbind-CN: -logKd/Ki=7.26,IC50=55nM
BindingDB: IC50=55nM
Gene Ontology
Molecular Function
GO:0004014 adenosylmethionine decarboxylase activity
Biological Process
GO:0008295 spermidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1i72, PDBe:1i72, PDBj:1i72
PDBsum1i72
PubMed11583147
UniProtP17707|DCAM_HUMAN S-adenosylmethionine decarboxylase proenzyme (Gene Name=AMD1)

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