Structure of PDB 1hxp Chain B

Receptor sequence
>1hxpB (length=329) Species: 562 (Escherichia coli) [Search protein sequence]
TQFNPVDHPHRRYNPLTGQWILVSPHRLPAHDPDCFLCAGNVRVTGDKNP
DYTGTYVFTNDFAALMSDTPDAPESHDPLMRCQSARGTSRVICFSPDHSK
TLPELSVAALTEIVKTWQEQTAELGKTYPWVQVFENKGAAMGCSNPHPHG
QIWANSFLPNEAEREDRLQKEYFAEQKSPMLVDYVQRELADGSRTVVETE
HWLAVVPYWAAWPFETLLLPKAHVLRITDLTDAQRSDLALALKKLTSRYD
NLFQCSFPYSMGWHGAPFNGEENQHWQLHAHFYPPLLRSATVRKFMVGYE
MLAETQRDLTAEQAAERLRAVSDIHFRES
3D structure
PDB1hxp Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) C52 C55 H115 N153 S161 H164 H166 Q168
Catalytic site (residue number reindexed from 1) C35 C38 H98 N136 S144 H147 H149 Q151
Enzyme Commision number 2.7.7.12: UDP-glucose--hexose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BME B F4 P6 H11 Y225 F3 P5 H10 Y208
BS02 ZN B C52 C55 H115 H164 C35 C38 H98 H147
BS03 FE B E182 H281 H296 H298 E165 H264 H279 H281
BS04 BME B N153 C160 Q168 N136 C143 Q151
BS05 UDP B R60 V61 F75 N77 D78 S161 N162 R43 V44 F58 N60 D61 S144 N145
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006012 galactose metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1hxp, PDBe:1hxp, PDBj:1hxp
PDBsum1hxp
PubMed7669762
UniProtP09148|GAL7_ECOLI Galactose-1-phosphate uridylyltransferase (Gene Name=galT)

[Back to BioLiP]