Structure of PDB 1hvi Chain B

Receptor sequence

>1hviB (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

3D structure

• PDB: 1hvi Structure-Based Inhibitors of HIV-1 Protease
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A77	B	R8 D25 G27 A28 D29 G48 G49	R8 D25 G27 A28 D29 G48 G49	PDBbind-CN: -logKd/Ki=10.92,Ki=12pM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1hvi, PDBe:1hvi, PDBj:1hvi
• PDBsum: 1hvi
• UniProt: O92139