Structure of PDB 1hr7 Chain B

Receptor sequence

>1hr7B (length=439) Species: 4932 (Saccharomyces cerevisiae)

PGTRTSKLPNGLTIATEYIPNTSSATVGIFVDAGSRAENVKNNGTAHFLQ
HLAFKGTQNRPQQGIELEIENIGSHLNAYTSRENTVYYAKSLQEDIPKAV
DILSDILTKSVLDNSAIERERDVIIRESEEVDKMYDEVVFDHLHEITYKD
QPLGRTILGPIKNIKSITRTDLKDYITKNYKGDRMVLAGAGAVDHEKLVQ
YAQKYFGHVPKSESPVPLGSPRGPLPVFCRGERFIKENTLPTTHIAIALE
GVSWSAPDYFVALATQAIVGNWDRAIGTGTNSPSPLAVAASQNGSLANSY
MSFSTSYADSGLWGMYIVTDSNEHNVRLIVNEILKEWKRIKSGKISDAEV
NRAKAQLKAALLLSLDGSTAIVEDIGRQVVTTGKRLSPEEVFEQVDKITK
DDIIMWANYRLQNKPVSMVALGNTSTVPNVSYIEEKLNQ

3D structure

• PDB: 1hr7 Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences.
• Chain: B
• Resolution: 2.55 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H70 Q73 H74 E143 E150
• Catalytic site (residue number reindexed from 1): H47 Q50 H51 E120 E127
• Enzyme Commision number: 3.4.24.64: mitochondrial processing peptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H70 H74 E150	H47 H51 E127

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005515 protein binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0006627 protein processing involved in protein targeting to mitochondrion

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0017087 mitochondrial processing peptidase complex

External links

• PDB: RCSB:1hr7, PDBe:1hr7, PDBj:1hr7
• PDBsum: 1hr7
• PubMed: 11470436
• UniProt: P10507|MPPB_YEAST Mitochondrial-processing peptidase subunit beta (Gene Name=MAS1)