Structure of PDB 1hpx Chain B

Receptor sequence

>1hpxB (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

3D structure

• PDB: 1hpx Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine.
• Chain: B
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27
• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	KNI	B	D25 G27 A28 D29 D30 V32 G48 G49 I50	D25 G27 A28 D29 D30 V32 G48 G49 I50	MOAD: Ki=5.5pM PDBbind-CN: -logKd/Ki=11.26,Ki=5.5pM

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1hpx, PDBe:1hpx, PDBj:1hpx
• PDBsum: 1hpx
• PubMed: 8590019
• UniProt: P03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)