Structure of PDB 1hkv Chain B

Receptor sequence
>1hkvB (length=446) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
NELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFR
SRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVA
LHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGE
AGIVQDVLVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFA
TDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIA
TVDLGGGLGISYLPSDDPPPIAELAAKLGTIVSDESTAVGLPTPKLVVEP
GRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYGAQ
YDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAVAA
TGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR
3D structure
PDB1hkv Crystal Structure of Mycobacterium Tuberculosis Diaminopimelate Decarboxylase, an Essential Enzyme in Bacterial Lysine Biosynthesis
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.20: diaminopimelate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS B H213 S216 R303 Y348 Y405 H212 S215 R302 Y347 Y404
BS02 PLP B K72 H213 G257 G258 E300 G302 R303 Y405 K71 H212 G256 G257 E299 G301 R302 Y404
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008836 diaminopimelate decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1hkv, PDBe:1hkv, PDBj:1hkv
PDBsum1hkv
PubMed12637582
UniProtP9WIU7|DCDA_MYCTU Diaminopimelate decarboxylase (Gene Name=lysA)

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