Structure of PDB 1hii Chain B

Receptor sequence
>1hiiB (length=99) Species: 11709 (Human immunodeficiency virus 2) [Search protein sequence]
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGI
GGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
3D structure
PDB1hii Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C20 B D25 G27 A28 D29 G48 G49 I50 P81 I82 D25 G27 A28 D29 G48 G49 I50 P81 I82 MOAD: Ki=53nM
PDBbind-CN: -logKd/Ki=7.28,Ki=53nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1hii, PDBe:1hii, PDBj:1hii
PDBsum1hii
PubMed7613867
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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