Structure of PDB 1h74 Chain B

Receptor sequence
>1h74B (length=296) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MKVRVKAPCTSANLGVGFDVFGLCLKEPYDVIEVEAIDDKEIIIEVDDKN
IPTDPDKNVAGIVAKKMIDDFNIGKGVKITIKKGVKAGSGLGSSAASSAG
TAYAINELFKLNLDKLKLVDYASYGELASSGAKHADNVAPAIFGGFTMVT
NYEPLEVLHIPIDFKLDILIAIPNISINTKEAREILPKAVGLKDLVNNVG
KACGMVYALYNKDKSLFGRYMMSDKVIEPVRGKLIPNYFKIKEEVKDKVY
GITISGSGPSIIAFPKEEFIDEVENILRDYYENTIRTEVGKGVEVV
3D structure
PDB1h74 Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E130 T183
Catalytic site (residue number reindexed from 1) E126 T179
Enzyme Commision number 2.7.1.39: homoserine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ILE B A16 N17 D23 H138 D140 N141 R187 R235 G260 A12 N13 D19 H134 D136 N137 R183 R231 G256
BS02 AGS B N62 V63 K87 A91 G92 G94 G96 S97 S98 S101 S133 N58 V59 K83 A87 G88 G90 G92 S93 S94 S97 S129
Gene Ontology
Molecular Function
GO:0004413 homoserine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006566 threonine metabolic process
GO:0009088 threonine biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h74, PDBe:1h74, PDBj:1h74
PDBsum1h74
PubMed11535056
UniProtQ58504|KHSE_METJA Homoserine kinase (Gene Name=thrB)

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