Structure of PDB 1h6f Chain B

Receptor sequence
>1h6fB (length=186) Species: 9606 (Homo sapiens) [Search protein sequence]
KDDPKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKY
ILLMDIIAADDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMS
KVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFR
TYLFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRD
3D structure
PDB1h6f Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R130 R131 K208 Y264 T270 I274 N277 F279 F283 R31 R32 K109 Y165 T171 I175 N178 F180 F184
BS02 dna B N211 S224 T262 P278 F279 K281 G282 N112 S125 T163 P179 F180 K182 G183
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1h6f, PDBe:1h6f, PDBj:1h6f
PDBsum1h6f
PubMed12005433
UniProtO15119|TBX3_HUMAN T-box transcription factor TBX3 (Gene Name=TBX3)

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