Structure of PDB 1gz6 Chain B

Receptor sequence
>1gz6B (length=278) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGSSAADKVVE
EIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSR
ISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFG
QANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNEALKPEYVAPLVLWL
CHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWVK
ICDFSNASKPKSIQESTGGIIEVLHKID
3D structure
PDB1gz6 Binary Structure of the Two-Domain (3R)-Hydroxyacyl-Coa Dehydrogenase from Rat Peroxisomal Multifunctional Enzyme Type 2 at 2.38 A Resolution
ChainB
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S151 Y164 K168
Catalytic site (residue number reindexed from 1) S141 Y154 K158
Enzyme Commision number 1.1.1.n12: (3R)-hydroxyacyl-CoA dehydrogenase.
4.2.1.107: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase.
4.2.1.119: enoyl-CoA hydratase 2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI B G16 L21 D40 L41 S75 V76 N99 A100 G101 H123 T149 S151 Y164 K168 P194 G14 L19 D38 L39 S65 V66 N89 A90 G91 H113 T139 S141 Y154 K158 P184
External links
PDB RCSB:1gz6, PDBe:1gz6, PDBj:1gz6
PDBsum1gz6
PubMed12517343
UniProtP97852|DHB4_RAT Peroxisomal multifunctional enzyme type 2 (Gene Name=Hsd17b4)

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