Structure of PDB 1gwq Chain B

Receptor sequence
>1gwqB (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKNSLALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHR
3D structure
PDB1gwq Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 D538 E542 M543 I52 K56 L66 V70 D232 E236 M237
BS02 ZTW B E353 L387 F404 M421 H524 L525 E47 L81 F98 M115 H218 L219 BindingDB: EC50=1400nM,IC50=1410nM,Ki=4.1nM
External links
PDB RCSB:1gwq, PDBe:1gwq, PDBj:1gwq
PDBsum1gwq
PubMed11937504
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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