Structure of PDB 1gqy Chain B

Receptor sequence
>1gqyB (length=469) Species: 727 (Haemophilus influenzae) [Search protein sequence]
EEIRKIIPEMRRVQQIHFIGIGGAGMSGIAEILLNEGYQISGSDIADGVV
TQRLAQAGAKIYIGHAEEHIEGASVVVVSSAIKDDNPELVTSKQKRIPVI
QRAQMLAEIMRFRHGIAVAGTHGKTTTTAMISMIYTQAKLDPTFVNGGLV
KSAGKNAHLGASRYLIAEADESDASFLHLQPMVSVVTNMEPDHMDTYEGD
FEKMKATYVKFLHNLPFYGLAVMCADDPVLMELVPKVGRQVITYGFSEQA
DYRIEDYEQTGFQGHYTVICPNNERINVLLNVPGKHNALNATAALAVAKE
EGIANEAILEALADFQGAGRRFDQLGEFIRPNGKVRLVDDYGHHPTEVGV
TIKAAREGWGDKRIVMIFQPHRYSRTRDLFDDFVQVLSQVDALIMLDVYA
AGEAPIVGADSKSLCRSIRNLGKVDPILVSDTSQLGDVLDQIIQDGDLIL
AQGAGSVSKISRGLAESWK
3D structure
PDB1gqy Crystal Structures of Udp-N-Acetylmuramate-L-Alanine Ligase (Murc) from Haemophilus Influenzae
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K129 T130 L154 E173 H198
Catalytic site (residue number reindexed from 1) K124 T125 L149 E168 H193
Enzyme Commision number 6.3.2.8: UDP-N-acetylmuramate--L-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B T126 H127 G128 K129 T130 T131 H291 N295 R326 D345 G347 H348 E352 T356 T121 H122 G123 K124 T125 T126 H286 N290 R321 D340 G342 H343 E347 T351
BS02 MG B T130 E173 T125 E168
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1gqy, PDBe:1gqy, PDBj:1gqy
PDBsum1gqy
PubMed
UniProtP45066|MURC_HAEIN UDP-N-acetylmuramate--L-alanine ligase (Gene Name=murC)

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