Structure of PDB 1gj7 Chain B

Receptor sequence
>1gj7B (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKEASTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB1gj7 Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H46 D97 Q195 G196 D197 S198 G199
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N26 W29 P49 P114 R116 Q119 T120 C122 M207 N11 W14 P38 P113 R115 Q118 T119 C121 M210
BS02 132 B H57 D189 S190 Q192 S195 V213 S214 W215 G219 C220 G226 V227 H46 D192 S193 Q195 S198 V216 S217 W218 G221 C222 G229 V230 MOAD: Ki=0.009uM
PDBbind-CN: -logKd/Ki=7.89,Ki=0.013uM
BindingDB: Ki=14nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1gj7, PDBe:1gj7, PDBj:1gj7
PDBsum1gj7
PubMed11731301
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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