Structure of PDB 1gfw Chain B

Receptor sequence
>1gfwB (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
HKIPVDADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH
ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
3D structure
PDB1gfw Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MSI B Y204 W206 R207 F256 Y20 W22 R23 F72 PDBbind-CN: -logKd/Ki=7.82,Ki=15nM
BindingDB: Ki=15nM,IC50=114nM,EC50=7670nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1gfw, PDBe:1gfw, PDBj:1gfw
PDBsum1gfw
PubMed10821855
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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