Structure of PDB 1g8h Chain B

Receptor sequence
>1g8hB (length=510) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PAPHGGILQDLIARDALKKNELLSEAQSSDILVWNLTPRQLCDIELILNG
GFSPLTGFLNENDYSSVVTDSRLADGTLWTIPITLDVDEAFANQIKPDTR
IALFQDDEIPIAILTVQDVYKPNKTIEAERVFRGDPEHPAISYLFNVAGD
YYVGGSLEAIQLPQHYDYPGLRKTPAQLRLEFQSRQWDRVVAFQTRNPMH
RAHRELTVRAAREANAKVLIHPVVGLTKPGDIDHHTRVRVYQEIIKRYPN
GIAFLSLLPLAMRMSGDREAVWHAIIRKNYGASHFIVGRDHAGPGKNSKG
VDFYGPYDAQELVESYKHELDIEVVPFRMVTYLPDEDRYAPIDQIDTTKT
RTLNISGTELRRRLRVGGEIPEWFSYPEVVKILRESNPPRPKQGFSIVLG
NSLTVSREQLSIALLSTFLQFGGGRYYKIFEHNNKTELLSLIQDFIGSGS
GLIIPDQWEDDKDSVVGKQNVYLLDTSSSADIQLESADEPISHIVQKVVL
FLEDNGFFVF
3D structure
PDB1g8h Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T196 R197 H201 H204 R290
Catalytic site (residue number reindexed from 1) T195 R196 H200 H203 R289
Enzyme Commision number 2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B E46 P164 H166 E45 P163 H165
BS02 ADX B F194 Q195 T196 R197 N198 H204 L207 G289 R290 H292 A293 R329 M330 V331 F193 Q194 T195 R196 N197 H203 L206 G288 R289 H291 A292 R328 M329 V330
BS03 POP B H204 N355 I356 F375 H203 N354 I355 F374
Gene Ontology
Molecular Function
GO:0004781 sulfate adenylyltransferase (ATP) activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0000103 sulfate assimilation
GO:0006790 sulfur compound metabolic process
GO:0010134 sulfate assimilation via adenylyl sulfate reduction
GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)
GO:0070814 hydrogen sulfide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Cellular Component
External links
PDB RCSB:1g8h, PDBe:1g8h, PDBj:1g8h
PDBsum1g8h
PubMed11157739
UniProtP08536|MET3_YEAST Sulfate adenylyltransferase (Gene Name=MET3)

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