Structure of PDB 1g50 Chain B

Receptor sequence
>1g50B (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQR
LAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL
3D structure
PDB1g50 Overexpression, Purification, and Crystal Structure of Native ER alpha LBD
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST B E1353 L1387 M1388 L1391 F1404 G1521 H1524 L1525 E50 L84 M85 L88 F101 G218 H221 L222 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1g50, PDBe:1g50, PDBj:1g50
PDBsum1g50
PubMed11437591
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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