Structure of PDB 1fv3 Chain B

Receptor sequence
>1fv3B (length=451) Species: 1513 (Clostridium tetani) [Search protein sequence]
KNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQL
VPGINGKAIHLVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSAS
HLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQI
TFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAI
REDNNITLKLDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFL
RDFWGNPLRYDTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNI
YYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKD
GNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNAS
LGLVGTHNGQIGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTN
D
3D structure
PDB1fv3 The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A922 K996
Catalytic site (residue number reindexed from 1) A58 K132
Enzyme Commision number 3.4.24.68: tentoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B D1222 T1270 H1271 W1289 D358 T406 H407 W425
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:1fv3, PDBe:1fv3, PDBj:1fv3
PDBsum1fv3
PubMed11418600
UniProtP04958|TETX_CLOTE Tetanus toxin (Gene Name=tetX)

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