Structure of PDB 1fll Chain B

Receptor sequence
>1fllB (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]
LESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETAS
YNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGD
GMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFK
PDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTS
DLPDP
3D structure
PDB1fll Molecular basis for CD40 signaling mediated by TRAF3.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R393 D399 G400 M401 K403 F410 F448 S456 A467 S468 G469 R94 D100 G101 M102 K104 F111 F149 S157 A168 S169 G170
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0008063 Toll signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0045087 innate immune response
GO:0050688 regulation of defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:1fll, PDBe:1fll, PDBj:1fll
PDBsum1fll
PubMed10984535
UniProtQ13114|TRAF3_HUMAN TNF receptor-associated factor 3 (Gene Name=TRAF3)

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