Structure of PDB 1fgg Chain B

Receptor sequence
>1fggB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
MTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGL
LAASGLLFTHLVVLTPHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQ
GVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVV
GFHTAWERPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLV
DPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
3D structure
PDB1fgg Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D196 E281
Catalytic site (residue number reindexed from 1) D109 E192
Enzyme Commision number 2.4.1.135: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D196 R310 D109 R221
BS02 UDP B P82 Y84 D113 R156 D194 D195 D196 H308 R310 P8 Y10 D39 R69 D107 D108 D109 H219 R221
Gene Ontology
Molecular Function
GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1fgg, PDBe:1fgg, PDBj:1fgg
PDBsum1fgg
PubMed10946001
UniProtO94766|B3GA3_HUMAN Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (Gene Name=B3GAT3)

[Back to BioLiP]